https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 The role of the blood-brain barrier during neurological disease and infection https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53016 Wed 28 Feb 2024 16:09:05 AEDT ]]> Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6935 Wed 11 Apr 2018 09:35:42 AEST ]]> New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41455 Wed 10 Aug 2022 12:11:24 AEST ]]> Integrin alpha v beta 6 plays a bi-directional regulation role between colon cancer cells and cancer-associated fibroblasts https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44798 Tue 08 Nov 2022 11:10:13 AEDT ]]> Current research into snake antivenoms, their mechanisms of action and applications https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37720 Thu 25 Mar 2021 11:51:59 AEDT ]]> Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44052 Thu 06 Oct 2022 08:58:07 AEDT ]]> Baroreflex control of coronary conductance in normotensive and renal hypertensive dogs with complete heart block https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12715 Sat 24 Mar 2018 08:16:19 AEDT ]]> Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17890 Sat 24 Mar 2018 07:56:25 AEDT ]]> Simple topology: FtsK-directed recombination at the dif site https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18361 Sat 24 Mar 2018 07:52:40 AEDT ]]> Ca²⁺oscillations and the cell cycle at fertilisation of mammalian and ascidian eggs https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6579 Sat 24 Mar 2018 07:49:17 AEDT ]]> The soluble sperm factor that causes Ca²⁺ release from sea-urchin (Lytechinus pictus) egg homogenates also triggers Ca²⁺ oscillations after injection into mouse eggs https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6581 Sat 24 Mar 2018 07:49:17 AEDT ]]> Different Ca²⁺-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6571 Sat 24 Mar 2018 07:49:16 AEDT ]]> Probing the interaction of tetraspanin CD151 with integrin α3β1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151-integrin α3β1 complex https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5526 Sat 24 Mar 2018 07:46:40 AEDT ]]> Complexes of 2,6-bis[N-(2'-pyridylmethyl)carbamyl]pyridine: formation of mononuclear complexes, and self-assembly of double helical dinuclear and tetranuclear copper(II) and trinuclear nickel(II) complexes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52 Sat 24 Mar 2018 07:42:01 AEDT ]]> A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22024 Sat 24 Mar 2018 07:15:46 AEDT ]]> Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38495 Mon 09 May 2022 16:16:36 AEST ]]> Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46097 P < 0.05, n = 5–8). The targeting of cGAS also attenuated etoposide-induced senescence in Ctrl-LFs (P < 0.05, n = 5–8). Levels of mitochondrial DNA (mDNA) detected by qPCR in the cytosol and medium of IPF-LFs or senescence-induced Ctrl-LFs were higher than Ctrl-LFs at baseline (P < 0.05, n = 5–7). The addition of DNAse I (100 U/ml) deaccelerated IPF-LF senescence (P < 0.05, n = 5), whereas ectopic mDNA or the induction of endogenous mDNA release augmented Ctrl-LF senescence in a cGAS-dependent manner (P < 0.05, n = 5). In conclusion, we provide evidence that cGAS reinforces lung fibroblast senescence involving damaged self DNA. The targeting of cGAS to supress senescent-like responses may have potential important therapeutic implications in the treatment of IPF.]]> Fri 11 Nov 2022 11:23:00 AEDT ]]>